Publications
2019
Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N.: The molecular basis for an allosteric inhibition of K+ -flux gating in K2P channels. Elife. 2019 Feb 26;8. pii: e39476. doi: 10.7554/eLife.39476. PMID: 30803485 |
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. : A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569 . PMID: 30792303 |
2018
Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print] PubMed PMID: 29879376. |
2017
Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure. 2017 Mar 24. pii: S0969-2126(17)30066-7. doi: 10.1016/j.str.2017.03.006. [Epub ahead of print] PubMed PMID: 28392258. |
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Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B, Schulze-Bahr E. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia. EMBO Mol Med. 2017 Apr;9(4):403-414. doi: 10.15252/emmm.201606690. PubMed PMID: 28242754; PubMed Central PMCID: PMC5376757. |
2016
McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. J Gen Physiol. 2016 Jun;147(6):497-505. doi: 10.1085/jgp.201611601. PubMed PMID: 27241700; PubMed Central PMCID: PMC4886281. |
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Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, de Groot BL, Tucker SJ, Rapedius M, Baukrowitz T. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell. 2016 Feb 25;164(5):937-49. doi: 10.1016/j.cell.2016.02.002. PubMed PMID: 26919430; PubMed Central PMCID: PMC4771873. |
2014
Fowler PW, Bollepalli MK, Rapedius M, Nematian-Ardestani E, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Insights into the structural nature of the transition state in the Kir channel gating pathway. Channels (Austin). 2014;8(6):551-5. doi: 10.4161/19336950.2014.962371. PubMed PMID: 25483285; PubMed Central PMCID: PMC4594414. |
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Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. State-dependent network connectivity determines gating in a K+ channel. Structure. 2014 Jul 8;22(7):1037-46. doi: 10.1016/j.str.2014.04.018. Epub 2014 Jun 26. PubMed PMID: 24980796; PubMed Central PMCID: PMC4087272. |
2013
Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2. PubMed PMID: 23728494; PubMed Central PMCID: PMC4539245. |
2012
Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin). 2012 Nov-Dec;6(6):473-8. doi: 10.4161/chan.22153. Epub 2012 Sep 18. PubMed PMID: 22991046; PubMed Central PMCID: PMC3536734. |
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Bista P, Meuth SG, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, Landgraf P, Borsotto M, Heurteaux C, Pape HC, Baukrowitz T, Budde T. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. Pflugers Arch. 2012 Jan;463(1):89-102. doi: 10.1007/s00424-011-1056-9. Epub 2011 Nov 15. PubMed PMID: 22083644. |
2011
Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. The pore structure and gating mechanism of K2P channels. EMBO J. 2011 Aug 5;30(17):3607-19. doi: 10.1038/emboj.2011.268. Erratum in: EMBO J. 2011 Nov 2;30(21):4515. Erhlich, Gunter [corrected to Ehrlich, Gunter]. PubMed PMID: 21822218; PubMed Central PMCID: PMC3181484. |
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Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ, Decher N. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286(16):13977-84. doi: 10.1074/jbc.M111.227884. Epub 2011 Mar 1. PubMed PMID: 21362619; PubMed Central PMCID: PMC3077598. |
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