Publications

2019

Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N.: 

The molecular basis for an allosteric inhibition of K+ -flux gating in K2P channels. Elife. 2019 Feb 26;8. pii: e39476. doi: 10.7554/eLife.39476. PMID: 30803485

Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. : 

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels.  Science. 2019 Feb 22;363(6429):875-880. doi: 10.1126/science.aav0569 . PMID: 30792303 

2018

Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018 Jun 7:fj201800246R. doi: 10.1096/fj.201800246R. [Epub ahead of print] PubMed PMID: 29879376.

https://www.ncbi.nlm.nih.gov/pubmed/29879376

2017

Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure. 2017 Mar 24. pii: S0969-2126(17)30066-7. doi: 10.1016/j.str.2017.03.006. [Epub ahead of print] PubMed PMID: 28392258.

https://www.ncbi.nlm.nih.gov/pubmed/28392258

  

Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B, Schulze-Bahr E. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia. EMBO Mol Med. 2017 Apr;9(4):403-414. doi: 10.15252/emmm.201606690. PubMed PMID: 28242754; PubMed Central PMCID: PMC5376757.

https://www.ncbi.nlm.nih.gov/pubmed/28242754

  

2016

McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. J Gen Physiol. 2016 Jun;147(6):497-505. doi: 10.1085/jgp.201611601. PubMed PMID: 27241700; PubMed Central PMCID: PMC4886281.

https://www.ncbi.nlm.nih.gov/pubmed/27241700

  

Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, de Groot BL, Tucker SJ, Rapedius M, Baukrowitz T. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell. 2016 Feb 25;164(5):937-49. doi: 10.1016/j.cell.2016.02.002. PubMed PMID: 26919430; PubMed Central PMCID: PMC4771873.

https://www.ncbi.nlm.nih.gov/pubmed/26919430

  

2014

Fowler PW, Bollepalli MK, Rapedius M, Nematian-Ardestani E, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Insights into the structural nature of the transition state in the Kir channel gating pathway. Channels (Austin). 2014;8(6):551-5. doi: 10.4161/19336950.2014.962371. PubMed PMID: 25483285; PubMed Central PMCID: PMC4594414.

https://www.ncbi.nlm.nih.gov/pubmed/25483285

  

Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. State-dependent network connectivity determines gating in a K+ channel. Structure. 2014 Jul 8;22(7):1037-46. doi: 10.1016/j.str.2014.04.018. Epub 2014 Jun 26. PubMed PMID: 24980796; PubMed Central PMCID: PMC4087272.

https://www.ncbi.nlm.nih.gov/pubmed/24980796

  

2013

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nat Chem Biol. 2013 Aug;9(8):507-13. doi: 10.1038/nchembio.1271. Epub 2013 Jun 2. PubMed PMID: 23728494; PubMed Central PMCID: PMC4539245.

https://www.ncbi.nlm.nih.gov/pubmed/23728494

  

2012

Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin). 2012 Nov-Dec;6(6):473-8. doi: 10.4161/chan.22153. Epub 2012 Sep 18. PubMed PMID: 22991046; PubMed Central PMCID: PMC3536734.

https://www.ncbi.nlm.nih.gov/pubmed/22991046

  

Bista P, Meuth SG, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, Landgraf P, Borsotto M, Heurteaux C, Pape HC, Baukrowitz T, Budde T. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. Pflugers Arch. 2012 Jan;463(1):89-102. doi: 10.1007/s00424-011-1056-9. Epub 2011 Nov 15. PubMed PMID: 22083644.

https://www.ncbi.nlm.nih.gov/pubmed/22083644

  

2011

Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. The pore structure and gating mechanism of K2P channels. EMBO J. 2011 Aug 5;30(17):3607-19. doi: 10.1038/emboj.2011.268. Erratum in: EMBO J. 2011 Nov 2;30(21):4515. Erhlich, Gunter [corrected to Ehrlich, Gunter]. PubMed PMID: 21822218; PubMed Central PMCID: PMC3181484.

https://www.ncbi.nlm.nih.gov/pubmed/21822218

  

Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ, Decher N. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286(16):13977-84. doi: 10.1074/jbc.M111.227884. Epub 2011 Mar 1. PubMed PMID: 21362619; PubMed Central PMCID: PMC3077598.

https://www.ncbi.nlm.nih.gov/pubmed/21362619

  

 

2010

Paynter JJ, Shang L, Bollepalli MK, Baukrowitz T, Tucker SJ. Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels. Channels (Austin). 2010 Sep-Oct;4(5):390-7. doi: 10.4161/chan.4.5.13006. Epub 2010 Sep 1. PubMed PMID: 20699659; PubMed Central PMCID: PMC3051873.

https://www.ncbi.nlm.nih.gov/pubmed/20699659

  

Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, Sterner C, Tegtmeier I, Penton D, Baukrowitz T, Hulton SA, Witzgall R, Ben-Zeev B, Howie AJ, Kleta R, Bockenhauer D, Warth R. KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14490-5. doi: 10.1073/pnas.1003072107. Epub 2010 Jul 22. PubMed PMID: 20651251; PubMed Central PMCID: PMC2922599.

https://www.ncbi.nlm.nih.gov/pubmed/20651251

  

Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T, Daut J. RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J. 2010 Jul 7;29(13):2101-13. doi: 10.1038/emboj.2010.88. Epub 2010 May 11. PubMed PMID: 20461057; PubMed Central PMCID: PMC2905254.

https://www.ncbi.nlm.nih.gov/pubmed/20461057

  

Kurata HT, Rapedius M, Kleinman MJ, Baukrowitz T, Nichols CG. Voltage-dependent gating in a "voltage sensor-less" ion channel. PLoS Biol. 2010 Feb 23;8(2):e1000315. doi: 10.1371/journal.pbio.1000315. PubMed PMID: 20208975; PubMed Central PMCID: PMC2826373.

https://www.ncbi.nlm.nih.gov/pubmed/20208975

  

Li X, Rapedius M, Baukrowitz T, Liu GX, Srivastava DK, Daut J, Hanley PJ. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800(3):385-91. doi: 10.1016/j.bbagen.2009.11.012. Epub 2009 Nov 18. PubMed PMID: 19931596.

https://www.ncbi.nlm.nih.gov/pubmed/19931596

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2008

Tucker SJ, Baukrowitz T. How highly charged anionic lipids bind and regulate ion channels. J Gen Physiol. 2008 May;131(5):431-8. doi: 10.1085/jgp.200709936. Epub 2008 Apr 14. Review. PubMed PMID: 18411329; PubMed Central PMCID: PMC2346576.

https://www.ncbi.nlm.nih.gov/pubmed/18411329

  

2007

Rapedius M, Paynter JJ, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing. Channels (Austin). 2007 Sep-Oct;1(5):327-30. Epub 2007 Oct 15. PubMed PMID: 18690035.

https://www.ncbi.nlm.nih.gov/pubmed/18690035

  

Rapedius M, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron. 2007 Aug 16;55(4):602-14. PubMed PMID: 17698013; PubMed Central PMCID: PMC1950231.

https://www.ncbi.nlm.nih.gov/pubmed/17698013

  

2006

Shumilina E, Klöcker N, Korniychuk G, Rapedius M, Lang F, Baukrowitz T. Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels. J Physiol. 2006 Sep 1;575(Pt 2):433-42. Epub 2006 Jun 15. PubMed PMID: 16777940; PubMed Central PMCID: PMC1819462.

https://www.ncbi.nlm.nih.gov/pubmed/16777940

  

Rapedius M, Haider S, Browne KF, Shang L, Sansom MS, Baukrowitz T, Tucker SJ. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel. EMBO Rep. 2006 Jun;7(6):611-6. Epub 2006 Apr 21. PubMed PMID: 16641935; PubMed Central PMCID: PMC1479598.

https://www.ncbi.nlm.nih.gov/pubmed/16641935

  

2005

Rapedius M, Soom M, Shumilina E, Schulze D, Schönherr R, Kirsch C, Lang F, Tucker SJ, Baukrowitz T. Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. J Biol Chem. 2005 Sep 2;280(35):30760-7. Epub 2005 Jun 24. PubMed PMID: 15980413.

https://www.ncbi.nlm.nih.gov/pubmed/15980413

  

2004

Kurata HT, Phillips LR, Rose T, Loussouarn G, Herlitze S, Fritzenschaft H, Enkvetchakul D, Nichols CG, Baukrowitz T. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. J Gen Physiol. 2004 Nov;124(5):541-54. Epub 2004 Oct 11. PubMed PMID: 15477380; PubMed Central PMCID: PMC2234007.

https://www.ncbi.nlm.nih.gov/pubmed/15477380

  

Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science. 2004 Apr 9;304(5668):265-70. Epub 2004 Mar 18. PubMed PMID: 15031437.

https://www.ncbi.nlm.nih.gov/pubmed/15031437

  

2003

Schulze D, Rapedius M, Krauter T, Baukrowitz T. Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP inhibition of KATP channels by the same mechanism. J Physiol. 2003 Oct 15;552(Pt 2):357-67. PubMed PMID: 14561820; PubMed Central PMCID: PMC2343384.

https://www.ncbi.nlm.nih.gov/pubmed/14561820

  

Schulze D, Krauter T, Fritzenschaft H, Soom M, Baukrowitz T. Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus. J Biol Chem. 2003 Mar 21;278(12):10500-5. Epub 2003 Jan 4. PubMed PMID: 12514171.

https://www.ncbi.nlm.nih.gov/pubmed/12514171

  

2001

Krauter T, Ruppersberg JP, Baukrowitz T. Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP. Mol Pharmacol. 2001 May;59(5):1086-93. PubMed PMID: 11306691.

https://www.ncbi.nlm.nih.gov/pubmed/11306691

  

2000

Baukrowitz T, Fakler B. KATP channels gated by intracellular nucleotides and phospholipids. Eur J Biochem. 2000 Oct;267(19):5842-8. Review. PubMed PMID: 10998043.

https://www.ncbi.nlm.nih.gov/pubmed/10998043

  

Oliver D, Baukrowitz T, Fakler B. Polyamines as gating molecules of inward-rectifier K+ channels. Eur J Biochem. 2000 Oct;267(19):5824-9. Review. PubMed PMID: 10998040.

https://www.ncbi.nlm.nih.gov/pubmed/10998040

  

Baukrowitz T. Inward rectifier potassium channels and a multitude of intracellular gating molecules. Eur J Biochem. 2000 Oct;267(19):5823. PubMed PMID: 10998039.

https://www.ncbi.nlm.nih.gov/pubmed/10998039

  

Baukrowitz T, Fakler B. K(ATP) channels: linker between phospholipid metabolism and excitability. Biochem Pharmacol. 2000 Sep 15;60(6):735-40. Review. PubMed PMID: 10930527.

https://www.ncbi.nlm.nih.gov/pubmed/10930527

  

Oliver D, Klöcker N, Schuck J, Baukrowitz T, Ruppersberg JP, Fakler B. Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron. 2000 Jun;26(3):595-601. PubMed PMID: 10896156.

https://www.ncbi.nlm.nih.gov/pubmed/10896156

  

1999

Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B. NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1. J Biol Chem. 1999 Dec 10;274(50):35521-5. PubMed PMID: 10585425.

https://www.ncbi.nlm.nih.gov/pubmed/10585425

  

Antz C, Bauer T, Kalbacher H, Frank R, Covarrubias M, Kalbitzer HR, Ruppersberg JP, Baukrowitz T, Fakler B. Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nat Struct Biol. 1999 Feb;6(2):146-50. PubMed PMID: 10048926.

https://www.ncbi.nlm.nih.gov/pubmed/10048926

  

Baukrowitz T, Tucker SJ, Schulte U, Benndorf K, Ruppersberg JP, Fakler B. Inward rectification in KATP channels: a pH switch in the pore. EMBO J. 1999 Feb 15;18(4):847-53. PubMed PMID: 10022827; PubMed Central PMCID: PMC1171177.

https://www.ncbi.nlm.nih.gov/pubmed/10022827

  

1998

Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science. 1998 Nov 6;282(5391):1141-4. PubMed PMID: 9804555.

https://www.ncbi.nlm.nih.gov/pubmed/9804555

  

1996

Baukrowitz T, Yellen G. Two functionally distinct subsites for the binding of internal blockers to the pore of voltage-activated K+ channels. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13357-61. PubMed PMID: 8917595; PubMed Central PMCID: PMC24097.

https://www.ncbi.nlm.nih.gov/pubmed/8917595

  

Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 1996 Feb 29;379(6568):833-6. PubMed PMID: 8587608.

https://www.ncbi.nlm.nih.gov/pubmed/8587608

  

Baukrowitz T, Yellen G. Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel. Science. 1996 Feb 2;271(5249):653-6. PubMed PMID: 8571129.

https://www.ncbi.nlm.nih.gov/pubmed/8571129

  

1995

Baukrowitz T, Yellen G. Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron. 1995 Oct;15(4):951-60. PubMed PMID: 7576643.

https://www.ncbi.nlm.nih.gov/pubmed/7576643

  

1994

Baukrowitz T, Hwang TC, Nairn AC, Gadsby DC. Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle. Neuron. 1994 Mar;12(3):473-82. PubMed PMID: 7512348.

https://www.ncbi.nlm.nih.gov/pubmed/7512348

  

Gadsby DC, Hwang TC, Baukrowitz T, Nagel G, Horie M, Nairn AC. Regulation of CFTR channel gating. Jpn J Physiol. 1994;44 Suppl 2:S183-92. PubMed PMID: 7752525.

https://www.ncbi.nlm.nih.gov/pubmed/7752525

  
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