Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels.
Cordeiro S, Finol-Urdaneta RK, Köpfer D, Markushina A, Song J, French RJ, Kopec W, de Groot BL, Giacobassi MJ, Leavitt LS, Raghuraman S, Teichert RW, Olivera BM, Terlau H.
Proc Natl Acad Sci U S A. 2018 Dec 28. pii: 201813161. doi: 10.1073/pnas.1813161116. [Epub ahead of print]


Subtype-specific block of voltage-gated K+ channels by μ-conopeptides.

Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH.

Biochem Biophys Res Commun. 2017 482(4):1135-1140.







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  • Becker, S. and Terlau, H.: Toxins from cone snails: properties, applications and biotechnological production. Applied Microbiology and Biotechnology, 79, 1 - 9 (2008).
  • Imperial, J.S., Chen, P., Sporning, A., Terlau, H., Daly, N.L., Craik, D.J., Alewood P.F. and Olivera, B.M.: Tyrosine-rich conopeptides affect voltage gated K+ channels. J. Biological Chemistry, 283, 23026 - 23032 (2008).


  • Zhang, M.-M., Green, B.R., Catlin, P., Fiedler, B., Azam, L., Chadwick, A., Terlau, H., McArthur, J.R., French, R.J., Gulyas, J., Rivier, J.E., Smith, B.J., Norton, R.S., Olivera, B.M., Yoshikami, D., and Bulaj, G.: Structure/function characterization of -conotoxin KIIIA, an analgesic, nearly irreversible blocker of neuronal mammalian sodium channels. J. Biological Chemistry, 282, 30699 - 30706 (2007).
  • Leipold, E., De Bie, H., Zorn, S., Borges, A., Olivera, B.M., Terlau, H., and Heinemann, S.H.: O-conotoxins prevent Nav channels from opening by interacting with the voltage sensor in domain-2. Channels, 1, 253 - 262 (2007).
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  • Teichert, R.W., Jacobson, R., Terlau, H., Yoshikami, D., and Olivera, B.M.: Discovery and characterization of the short A-conotoxins: A novel subfamily of excitatory conotoxins. Toxicon, 49, 318 - 328 (2007).


  • Terlau, H. and Kirchhoff, F.: Electrical excitability of vertebrate membranes/Voltage-gated ion channels. Encyclopedic Reference of Genomics and Proteonomics in Molecular Medicine, Part 9, 913 -916 (2006).
  • Finol-Urdaneta, R.K., Strüver, N. and Terlau, H.: Molecular and functional differences between heart mKv1.7 channel isoforms. J. General Physiology, 128, 133 - 145 (2006).
  • Imperial J., Bansal P.S., Alewood P.F., Daly N.L., Craik D.J., Sporning A., Terlau H., Lopez - Vera E., Bandyopadhyay P.K. and Olivera B.M.: A Novel Conotoxin Inhibitor of Kv1.6 Channel and nAChR Subtypes Defines a New Superfamily of Conotoxins. Biochemistry, 45, 8331 - 8340 (2006).
  • Bulaj, G., Zhang M., Layer R.T., Wei, S., Nielsen, J.S., Low, S.J., Klein, B.D., Wagstaff, J.D., Chicoine L., Harty, T.P., Terlau, H., Yoshikami, D., and Olivera, B.M.: Synthetic O-conotoxin MrVIB blocks TTX-resistant sodium channels and has long-lasting antinociceptive activity. Biochemistry, 45, 7404 - 7414 (2006).
  • Bayrhuber, M., Graf, R., Ferber, M., Zweckstetter, M., Imperial, J., Garrett, J.E., Olivera, B.M., Terlau, H. and Becker, S.: Production of recombinant Conkunitzin-S1 in Escherichia coli. Protein Expression and Purification 47, 640 -644 (2006).
  • Zorn, S., Leipold, E., Hansel, A., Bulaj, G., Olivera, B.M., Terlau, H., and Heinemann S.H. The µO-Conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3. FEBS Letters, 580, 1360 - 1364 (2006).


  • Leipold, E., Hansel, A., Olivera, B.M., Terlau, H. and Heinemann, S.H.: Molecular interaction of -conotoxins with voltage-gated sodium channels. FEBS Letters, 579, 3881 - 3884 (2005).
  • Bayrhuber, M., Vijayan, V. Ferber, M., Graf, R., Korukottu, J., Imperial, J., Garrett, J.E., Olivera, B.M., Terlau, H., Zweckstetter M. and Becker, S.: Conkunitzin-S1 is the first member of a new Kunitz-type conotoxin family - structural and functional characterization. J. Biological Chemistry, 280, 23766-23770 (2005).
  • Verdier, L., Al-Sabi, A., Rivier, J.E.F., Olivera, B.M., Terlau, H. and Carlomagno T.: Identification of a novel pharmacophore for peptide toxins interacting with K+ channels. J. Biological Chemistry, 280, 21246 - 21255 (2005).


  • French, R. and Terlau, H.: Neurotoxic peptides acting on sodium channels - Receptor targeting and therapeutic potential. Current Medicinal Chemistry, 11, 3053 - 3064 (2004).
  • Terlau, H. and Olivera, B.M.: Conus venoms: A rich source of novel ion channel-targeted peptides. Physiological Reviews, 84, 41 - 68 (2004).
  • Boccaccio, A., Conti, F., Olivera, B.M. and Terlau, H.: Binding of -conotoxin PVIIA to Shaker K+ channels reveals different K+ and Rb+ occupancies within the ion channel pore. J. General Physiology, 124, 71 - 81 (2004).
  • Al-Sabi, A., Lennarz, D., Ferber, M., Gulyas, J., Rivier, J., Olivera, B.M., Carlomagno T. and Terlau H.: M-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry, 43, 8625 - 8635 (2004).
  • Ferber, M., Al-Sabi, A., Stocker, M., Olivera B.M. and Terlau, H.: Identification of a mammalian target of M-conotoxin RIIIK. Toxicon, 43, 915 - 921 (2004).
  • Koch, D.E., Olivera, B.M., Terlau, H. and Conti, F.: The binding of -conotoxin PVIIA and fast C-type inactivation Shaker K+-channels are mutally exclusive. Biophysical Journal, 86, 191 - 209 (2004).


  • Tietze, L.F., Sommer, K.M., Schneider, G., Tapolsányi, P., Wölfing, J., Müller P., Noltemeyer, M. and Terlau H.: Novel medium ring sized estradiol derivatives by intramolecular heck reactions. Synlett, 10, 1494 - 1496 (2003).
  • Ferber, M., Sporning, A., Jeserich, G., DeLaCruz, R., Watkins, M., Olivera, B.M. and Terlau, H.: A novel Conus peptide ligand for K+ channels. J. Biological Chemistry, 278, 2177 - 2183 (2003).


  • Peters, L., König, G.M., Terlau, H. and Wright, A.D.: Four new bromotryptamine derivatives from the marine bryozoan Flustra foliacea. J. Natural Products, 65, 1633 - 1637 (2002).


  • Zeeck, A., Bach, G. and Terlau, H.: Das medizinische Potential von Naturstoffen. Der Internist, 42, 1422 - 1427 (2001).


  • Terlau, H., Bach, G. and Zeeck, A.: Das medizinische Potential von Naturstoffen. Der Gynäkologe 33, 6 - 10 (2000). Auch erschienen in: Der Urologe [B] 40, 266 - 270 (2000).
  • Jacobson, R.B., Koch E.D., Lange-Malecki, B., Stocker, M., Verhey, J., Van Wagoner, R.M., Vyazovkina, A., Olivera, B.M. and Terlau, H.: Single amino acid substitutions in -conotoxin PVIIA disrupt interaction with the Shaker channel. J. Biological Chemistry, 275, 24639 - 24644 (2000).
  • Nguyen, T.-D., Rabe, H., Terlau, H. and Jeserich, G.: Isolation and heterologous expression of two genomic clones encoding Shaker-related potassium channels of trout CNS. J. Neuroscience Research, 60, 174 - 183 (2000).


  • Terlau, H.: Conotoxine - Neurotoxische Peptide mit erstaunlicher Vielfalt und Spezifität. Neuroforum 3/99, 92 - 98 (1999).
  • Terlau, H., Bocaccio, A., Olivera, B.M. and Conti, F.: The block of Shaker K+ channels by -conotoxin PVIIA is state dependent. J. General Physiology, 114, 125 - 140 (1999).
  • Schönherr, R., Hehl, S., Terlau, H., Baumann, A. and Heinemann, S.H.: Individual subunits contribute independently to slow gating of bovine EAG potassium channels. J. Biological Chemistry, 274, 5362 - 5369 (1999).


  • Terlau, H. and Stühmer, W.: Structure and function of voltage-gated ion channels. Naturwissenschaften 85, 437 - 444 (1998).
  • Craig, A.G., Zafarella, G., Cruz, L.J., Santos, A.D., Hillyard, D.R., Dykert, J., Rivier, J.E., Gray, W.R., Imperial, J., DelaCruz, R.G., Sporning, A., Terlau, H., West, P.J., Yoshikami, D. and Olivera, B.M.: An O-glycosylated neuroexitatory Conus peptide. Biochemistry, 37, 16019 - 16025 (1998).
  • Shon, K.-J., Olivera, B.M., Marsh, M., Jacobson, R., Gray, W.R., Floresca, C.Z., Cruz, L.J., Hillyard, D., Brink, A., Terlau, H. and Yoshikami, D.: -conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes. J. Neuroscience, 18, 4473 - 4481 (1998).
  • Shon, K.-J., Stocker, M., Terlau, H., Stühmer, W., Jacobson, R., Walker, C., Grilley, M., Marsh, M., Hillyard, D., Gray, W.R. and Olivera, B.M.: -conotoxin PVIIa: A peptide inhibiting the Shaker K+ channel. J. Biological Chemistry, 273, 33 - 38 (1998).


  • Terlau, H., Heinemann, S.H., Stühmer, W., Pongs, O. and Ludwig, J.: Amino-terminal dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. J. Physiology, 502, 537 - 543 (1997).
  • Terlau, H.: Wie Schnecken Fische fangen. Erkenntnisse für die Hirnforschung. DFG-Forschung 4-1996. Auch erschienen in: Abenteuer Natur, 4/1997. Ins Englische übersetzt erschienen in: German Research, Reports of the DFG 2-3/1997.


  • Terlau, H., Shon, K.-J., Grilley, M., Stocker, M., Stühmer, W. and Olivera, B.M.: Strategy for rapid immobilization of prey by a fish-hunting marine snail. Nature, 381, 148 - 151 (1996).
  • Terlau, H., Stocker M., Shon, K.-J., McIntosh, J.M. and Olivera, B.M.: O-conotoxin MRVIa inhibits mammalian sodium channels but not through site I. J. Neurophysiology, 76, 1423 - 1429 (1996).
  • Parekh, A.B. and Terlau, H.: Effects of protein phosphorylation on the regulation of capacitative calcium influx in Xenopus oocytes. Pflügers Archiv, 432, 14 - 25 (1996).
  • Terlau, H., Ludwig, J., Steffan, R., Pongs, O., Stühmer, W. and Heinemann, S.H.: Extracellular Mg2+ regulates activation of rat eag potassium channel. Pflügers Archiv, 432, 301 - 312 (1996).


  • Schlingensiepen, R., Terlau, H., Brysch, W. and Schlingensiepen, K.-H.: Differential expression of c-jun, junB and junD in rat hippocampal slices. NeuroReport, 6, 101-104 (1994).
  • Ludwig, J., Terlau, H., Wunder, F., Brüggemann, A., Pardo, L.A. Marquardt, A., Stühmer, W. and Pongs, O.: Functional expression of a rat homologue of the voltage gated ether á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO Journal, 13, 4451-4458 (1994).


  • Parekh, A.B., Terlau, H. and Stühmer, W.: Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger. Nature, 364, 814-818 (1993).


  • Stühmer, W., Terlau, H. and Heinemann, S.H.: Two electrode and patch clamp recordings from Xenopus oocytes In: Practical electrophysiological methods. H. Kettenmann, R. Grantyn (Eds.) Wiley-Liss (1992).
  • Pardo, L.A., Heinemann, S.H., Terlau, H., Ludewig, U., Lorra, C., Pongs, O. and Stühmer, W.: Extracellular K+ specifically modulates a rat brain K+ channel. Proc. Natl. Acad. Sci., 89, 2466-2470 (1992).
  • Heinemann, S.H., Terlau, H. and Imoto, K.: Molecular basis for pharmacological differences between brain and cardiac sodium channel. Pflügers Archiv, 422, 90-92 (1992).
  • Heinemann, S.H., Terlau, H., Stühmer, W., Imoto, K. and Numa, S.: Calcium channel characteristics conferred on the sodium channel by single mutations. Nature, 356, 441-443 (1992).


  • Terlau, H., Heinemann, S.H., Stühmer, W. , Pusch, M., Conti, F., Imoto, K. and Numa, S.: Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Letters, 293 , 93-96 (1991).


  • Seifert, W., Förster, F., Flott, B. and Terlau, H.: Effects of a neurotrophic factor (FGF) on development, regeneration and synaptic plasticity of central neurons. In: Excitatory amino acids and neuronal plasticity, Y. Ben-Ari (Ed.), Plenum Press (1990).
  • Terlau, H. and Seifert, W.: Fibroblast growth factor enhances long-term potentiation in the hippocampal slice. European J. Neuroscience, 2, 973-977 (1990).


  • Terlau, H. and Seifert, W.: Influence of epidermal growth factor on long-term potentiation in the hippocampal slice. Brain Research, 484 , 352-356 (1989).


  • Seifert, W., Terlau, H. and Schmidt, R.: A possible role for ependymin in hippocampal plasticity. In: Modulation of synaptic transmission and plasticity in nervous systems, G. Herting and H.-C. Spatz (Eds.) Springer-Verlag (1988).
  • Seifert, W., Wieraszko, A. and Terlau, H.: Gangliosides and synaptic plasticity in the hippocampus. In: Synaptic plasticity in the hippocampus, H.L. Haas, G. Buzaki (Eds. Springer-Verlag (1988).
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