The brain is made of large numbers of diverse neuronal cell types, which are wired up in various configurations across different brain regions. To adequately process information these neurons have to communicate with each other and work together as a circuit. Dysfunction of individual neuronal subclasses will lead to pathological information-processing and may contribute to different neurological and psychiatric disorders. We are trying to understand the relevance of individual cellular components within circumscribed neuronal circuits for neuronal network operations and behavioural performance. We are particularly interested in neuronal circuits involved in the production of spatial and emotional memory.
Methods we use include:
Virus production and stereotaxic injections
Fluorescent immunohistochemistry and in situ hybridization
Neuronal tracing and immediate early gene imaging
Local field potential recordings