Publications
2017
- Thomsen J, Ramesh K, Sanders T, Bleich M, Melzner F. Calcification in a marginal sea – influence of seawater [Ca2+] and carbonate chemistry on bivalve shell formation. Biogeosciences. doi.org/10.5194/bg-2017-342 Epub Sept 2017
- Taubner I, Böhm F, Eisenhauer A, Tambutté E, Tambutté S, Moldzio S, Bleich M. An improved approach investigating epithelial ion transport in scleractinian corals. LIMNOLOGY AND OCEANOGRAPHY 15,9: 753-765 (2017)
- Gong Y, Himmerkus N, Sunq A, Milatz S, Merkel C, Bleich M, Hou J. ILDR1 is important for paracellular water transport and urine concentration mechanism. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5271-5276. doi: 10.1073/pnas.1701006114. Epub 2017 May 1.
- Hu MY, Sung PH, Guh YJ, Lee JR, Hwang PP, Weihrauch D, Tseng YC. Perfused Gills Reveal Fundamental Principles of pH Regulation and Ammonia Homeostasis in the Cephalopod Octopus vulgaris. Front Physiol. 2017 Mar 20;8:162. doi: 10.3389/fphys.2017.00162. eCollection 2017.
- Bleich M, Günzel D. Physiology, pathophysiology, and clinical impact of claudins. Pflugers Arch. 2017 Jan;469(1):1-2. doi: 10.1007/s00424-016-1918-2. Epub 2016 Dec 6. No abstract available.
- Himmerkus N., Leipziger J. Wie machen Schleifendiuretika den Urin sauer? Der Nephrologe, Ausgabe 2/2017
- Himmerkus N, Plain A, Marques RD, Sonntag SR, Paliege A, Leipziger J, Bleich M. (2016) AVP dynamically increases paracellular Na+ permeability and transcellular NaCl transport in the medullary thick ascending limb of Henle's loop. 2016 Dec 6. Pflugers Arch.[Epub ahead of print] Review.PMID: 27924355
- Milatz S, Himmerkus N, Wulfmeyer VC, Drewell H, Mutig K, Hou J, Breiderhoff T, Müller D, Fromm M, Bleich M, Günzel D. (2016) Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E219-E227. doi: 10.1073/pnas.1611684114. Epub 2016 Dec 27.
- Milatz S, Breiderhoff T. (2016) One gene, two paracellular ion channels-claudin-10 in the kidney. Pflugers Arch. 2017 Jan;469(1):115-121. doi: 10.1007/s00424-016-1921-7. Epub 2016 Dec 10. Review.
- Klar J, Piontek J, Milatz S, Tariq M, Jameel M, Breiderhoff T, Schuster J, Fatima A, Asif M, Sher M, Mäbert K, Fromm A, Baig SM, Günzel D, Dahl N. (2017) Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. PLoS Genet. 2017 Jul 7;13(7):e1006897. doi: 10.1371/journal.pgen.1006897. [Epub ahead of print]
PMID:28686597 - Bongers EMHF, Shelton LM, Milatz S, Verkaart S, Bech AP, Schoots J, Cornelissen EAM, Bleich M, Hoenderop JGJ, Wetzels JFM, Lugtenberg D, Nijenhuis T. (2017) A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with CLDN10 Mutations. J Am Soc Nephrol. 2017 Jul 3. pii: ASN.2016080881. doi: 10.1681/ASN.2016080881. [Epub ahead of print]
PMID: 28674042 - Bleich M, Wulfmeyer VC, Himmerkus N, Milatz S. (2017) Heterogeneity of tight junctions in the thick ascending limb. Ann N Y Acad Sci. 2017 Jun 19. doi: 10.1111/nyas.13400. [Epub ahead of print] Review.
PMID: 28628195 - Breiderhoff T, Himmerkus N, Drewell H, Plain A, Günzel D, Mutig K, Willnow TE, Müller D, Bleich M. (2017) Deletion of claudin-10 rescues claudin-16-deficient mice from hypomagnesemia and hypercalciuria. Kidney Int. 2017 Nov 10. pii: S0085-2538(17)30667-1. doi: 10.1016/j.kint.2017.08.029. [Epub ahead of print]
PMID:29129401 - Sonntag SR, Ziemens A, Wulfmeyer VC, Milatz S, Bleich M, Himmerkus N. (2017) Diuretic state affects ascending thin limb tight junctions. Am J Physiol Renal Physiol. 2017 Sep 27:ajprenal.00419.2017. doi: 10.1152/ajprenal.00419.2017. [Epub ahead of print]
PMID: 28971992 - Ramesh K, Hu MY, Thomsen J, Bleich M, Melzner F. (2017) Mussel larvae modify calcifying fluid carbonate chemistry to promote calcification. Nat Commun. 2017 Nov 22;8(1):1709. doi: 10.1038/s41467-017-01806-8.
- Milatz S, Piontek J, Hempel C, Meoli L, Grohe C, Fromm A, Lee IM, El-Athman R, Günzel D. (2017) Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras. Ann N Y Acad Sci. 2017 Oct;1405(1):102-115. doi: 10.1111/nyas.13393. Epub 2017 Jun 20.
PMID: 28633196 - Hinze C, Ruffert J, Walentin K, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM. (2017) GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation. J Am Soc Nephrol. 2017 Dec 13. pii: ASN.2017030353. doi: 10.1681/ASN.2017030353. [Epub ahead of print]
- Hu M, Tseng YC, Su YH, Lein E, Lee HG, Lee JR, Dupont S, Stumpp M. (2017) Variability in larval gut pH regulation defines sensitivity to ocean acidification in six species of the Ambulacraria superphylum. Proc Biol Sci. 2017 Oct 11;284(1864). pii: 20171066. doi: 10.1098/rspb.2017.1066.
2016
- Marian Y. Hu, Ying-Jey Guh, Yi-Ta Shao, Pou-Long Kuan, Guan-Lin Chen, Jay-Ron Lee, Ming-Shiou Jeng, Yung-Che Tseng (2016) Strong ion regulatory abilities enable the crab Xenograpsus testudinatus to inhabit highly acidified marine vent systems, 2016 Jan 11, doi:10.3389/fphys.2016.00014
- Plain, Wulfmeyer, Milatz, Klietz, Hou, Bleich, Himmerkus (2016) Corticomedullary difference in the effects of dietary Ca(2+) on tight junction properties in thick ascending limbs of Henle's loop. Pflugers Arch. 2016 Feb;468(2):293-303. doi: 10.1007/s00424-015-1748-7. Epub 2015 Oct 26.
- Larsen CK, Jensen IS, Sorensen MV, de Bruijn PI, Bleich M, Praetorius HA, Leipziger J. (2016) Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. Am J Physiol Renal Physiol. 2016 May 15;310(10):F1035-46. doi: 10.1152/ajprenal.00010.2016.
- Penton D, Czogalla J, Wengi A, Himmerkus N, Loffing-Cueni D, Carrel M, Rajaram RD, Staub O, Bleich M, Schweda F, Loffing J. (2016) Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl- -dependent and independent mechanisms. J Physiol. 2016 Jul 25. doi: 10.1113/JP272504. [Epub ahead of print] PMID:27457700
- J. Thomsen1,2,*, N. Himmerkus2, N. Holland1, F. J. Sartoris3, M. Bleich2 and M. Tresguerres1,* (2016) Ammonia excretion in mytilid mussels is facilitated by ciliary
beating © 2016. Published by The Company of Biologists Ltd | Journal of Experimental Biology (2016) 219, 2300-2310 doi:10.1242/jeb.139550 - Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A. (2016) Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase. Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1198-F1210. doi: 10.1152/ajprenal.00062.2016. Epub 2016 Sep 28.
- Hu M.Y.; Michael K.; Kreiss C.; Hwang P-P.; Dupont S.; Tseng Y-C.; Lucassen M. (2016) Temperature Modulates the Effects of Ocean Acidification on Intestinal Ion Transport in Atlantic Cod, Gadus morhua. Front Physiol. 2016 Jun 2;7:198. doi: 10.3389/fphys.2016.00198. eCollection 2016.
- Hu M.Y. (2016) Effects of CO2 driven ocean acidification on ontogenetic stages of the cuttlefish Sepia officinalis Vie et Milieu, Life and Environment (66:57-63) (Invited review)
- Hu MY, Guh YJ, Shao YT, Kuan PL, Chen GL, Lee JR, Jeng MS, Tseng YC (2016) Strong Ion Regulatory Abilities Enable the Crab Xenograpsus testudinatus to Inhabit Highly Acidified Marine Vent Systems. Front Physiol. 2016 Feb 1;7:14. doi: 10.3389/fphys.2016.00014. eCollection 2016.
2015
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Meike Stumpp, Marian Y. Hu, Yung-Che Tseng, Ying-Jeh Guh , Yi-Chih Chen, Jr-Kai Yu, Yi-Hsien Su, Pung-Pung Hwang (2015) Evolution of extreme stomach pH in bilateria inferred from gastric alkalization mechanisms in basal deuterostomes. 2015 Jun 08. DOI: 10.1038/srep10421
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Julia D. Sigwart, Gillian Lyons, Artur Fink, Magdalena A. Gutowska, Darren Murray, Frank Melzner, Jonathan D. R. Houghton, Marian Yong-an Hu (2015) Elevated pCO2 drives lower growth and yet increased calcification in the early life history of the cuttlefish Sepia officinalis (Mollusca: Cephalopoda), 2015 Oct 29, doi:10.1093/icesjms/fsv188,ICES Journal of Marine Science
- Katharina Michael , Cornelia M. Kreiss, Marian Y. Hu, Nils Koschnick, Ulf Bickmeyer, Sam Dupont, Hans-O. Pörtner, Magnus Lucassen (2015) Adjustments of molecular key components of branchial ion and pH regulation in Atlantic cod (Gadus morhua) in response to ocean acidification and warming, 2015
Dec 11, doi:10.1016/j.cbpb.2015.12.006 - Marian Y Hu, Yung-Che Tseng (2015) Recent advances in understanding transepithelial acid-base regulation and excretion mechanisms in cephalopods, 2015 Jul 27, doi:10.1080/21688370.2015.1064196
- Lazelle RA, McCully BH, Terker AS, Himmerkus N, Blankenstein K, Mutig K, Bleich M, Bachmann S, Yang CL, Ellison DH (2015) Renal Deletion of 12 kDa FK506-Binding Protein Attenuates Tacrolimus-Induced Hypertension. J Am Soc Nephrol. 2015 Oct 2. pii: ASN.2015040466. [Epub ahead of print] PMID:26432904
- Basse WC, Gutowska MA, Findeisen U, Stumpp M, Dupont S, Jackson DJ, Himmerkus N, Melzner F, Bleich M. (2015) A sea urchin Na+K+2Cl- cotransporter is involved in the maintenance of calcification-relevant cytoplasmic cords in Strongylocentrotus droebachiensis larvae. Comp Biochem Physiol A Mol Integr Physiol. 2015 May 15. pii: S1095-6433(15)00118-X. doi: 10.1016/j.cbpa.2015.05.005. [Epub ahead of print]
- de Bruijn PI, Larsen CK, Frische S, Himmerkus N, Praetorius HA, Bleich M, Leipziger J (2015) Furosemide-induced urinary acidification is caused by pronounced H+ secretion in the thick ascending limb. Am J Physiol Renal Physiol. 2015 May 20:ajprenal.00154.2015. doi: 10.1152/ajprenal.00154.2015. [Epub ahead of print] PMID: 25995110
- Borschewski A, Himmerkus N, Boldt C, Blankenstein KI, McCormick JA, Lazelle R, Willnow TE, Jankowski V, Plain A, Bleich M, Ellison DH, Bachmann S, Mutig K. (2015) Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl- Cotransporter. J Am Soc Nephrol. 2015 May 12. pii: ASN.2014070728. [Epub ahead of print]
- Milatz S, Piontek J, Schulzke JD, Blasig IE, Fromm M, Günzel D. (2015) Probing the cis-arrangement of prototype tight junction proteins claudin-1 and claudin-3. Biochem J. 2015 Apr 7. [Epub ahead of print]
2014
- Gong Y, Himmerkus N, Plain A, Bleich M, Hou J. (2014) Epigenetic Regulation of MicroRNAs Controlling CLDN14 Expression as a Mechanism for Renal Calcium Handling. J Am Soc Nephrol. 2014 Jul 28. pii: ASN.2014020129.
- McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH. (2014) Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. J Clin Invest. 2014 Nov 3;124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24.
- Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S. (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. doi: 10.1073/pnas.1415518111. Epub 2014 Nov 10.
- de Bruijn PI, Bleich M, Praetorius HA, Leipziger J. (2014) P2X receptors trigger intracellular alkalization in isolated perfused mouse medullary thick ascending limb. Acta Physiol (Oxf). 2014 Nov 1. doi: 10.1111/apha.12417
- Pohl M, Shan Q, Petsch T, Styp-Rekowska B, Matthey P, Bleich M, Bachmann S, Theilig F. (2014) Short-Term Functional Adaptation of Aquaporin-1 Surface Expression in the Proximal Tubule, a Component of Glomerulotubular Balance. J Am Soc Nephrol. 2014 Sep 30. pii: ASN.2014020148.
2013
- Holtmann, W.C., Stumpp, M., Gutowska, M.A., Syre, S., Himmerkus, N., Melzner, F. & Bleich, M. (2013) Maintenance of coelomic fluid pH in sea urchins exposed to elevated CO2: the role of body cavity epithelia and stereom dissolution. Marine Biology, 160, 2631-2645.
- Stumpp, M., Hu, M., Casties, I., Saborowski, R., Bleich, M., Melzner, F. & Dupont, S. (2013) Digestion in sea urchin larvae impaired under ocean acidification. Nat Clim Change, 3, 1044-1049.
- Linkermann A, Heller JO, Prókai A, Weinberg JM, De Zen F, Himmerkus N, Szabó AJ, Bräsen JH, Kunzendorf U, Krautwald S. (2013) The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice. J Am Soc Nephrol. 2013 Jul 5. [Epub ahead of print]
- Jaureguiberry G, De la Dure-Molla M, Parry D, Quentric M, Himmerkus N, Koike T, Poulter J, Klootwijk E, Robinette SL, Howie AJ, Patel V, Figueres ML, Stanescu HC, Issler N, Nicholson JK, Bockenhauer D, Laing C, Walsh SB, McCredie DA, Povey S, Asselin A, Picard A, Coulomb A, Medlar AJ, Bailleul-Forestier I, Verloes A, Le Caignec C, Roussey G, Guiol J, Isidor B, Logan C, Shore R, Johnson C, Inglehearn C, Al-Bahlani S, Schmittbuhl M, Clauss F, Huckert M, Laugel V, Ginglinger E, Pajarola S, Spartà G, Bartholdi D, Rauch A, Addor MC, Yamaguti PM, Safatle HP, Acevedo AC, Martelli-Júnior H, Dos Santos Netos PE, Coletta RD, Gruessel S, Sandmann C, Ruehmann D, Langman CB, Scheinman SJ, Ozdemir-Ozenen D, Hart TC, Hart PS, Neugebauer U, Schlatter E, Houillier P, Gahl WA, Vikkula M, Bloch-Zupan A, Bleich M, Kitagawa H, Unwin RJ, Mighell A, Berdal A, Kleta R. (2013) Nephrocalcinosis (Enamel Renal Syndrome) Caused by Autosomal Recessive FAM20A Mutations. Nephron Physiol. 2013 Feb 23;122(1-2):1-6. [Epub ahead of print]
- Bronckers AL, Güneli N, Lüllmann-Rauch R, Schneppenheim J, Moraru AP, Himmerkus N, Bervoets TJ, Fluhrer R, Everts V, Saftig P, Schröder B. (2013) The intramembrane protease SPPL2A is critical for tooth enamel formation. J Bone Miner Res. 2013 Feb 20. doi: 10.1002/jbmr.1895. [Epub ahead of print]
- Saritas T, Borschewski A, McCormick JA, Paliege A, Dathe C, Uchida S, Terker A, Himmerkus N, Bleich M, Demaretz S, Laghmani K, Delpire E, Ellison DH, Bachmann S, Mutig K. (2013) SPAK Differentially Mediates Vasopressin Effects on Sodium Cotransporters. J Am Soc Nephrol. 2013 Feb;24(3):407-18. doi: 10.1681/ASN.2012040404. Epub 2013 Feb 7.
2012
- Stumpp M, Hu MY, Melzner F, Gutowska MA, Dorey N, Himmerkus N, Holtmann WC, Dupont ST, Thorndyke MC, Bleich M. (2012) Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18192-7. doi: 10.1073/pnas.1209174109. Epub 2012 Oct 17.
- Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D. (2012)Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6. doi: 10.1073/pnas.1203834109. Epub 2012 Aug 13.
- Bleich M, Shan Q, Himmerkus N. (2012) Calcium regulation of tight junction permeability. Ann N Y Acad Sci. 2012 Jul;1258:93-9. doi: 10.1111/j.1749-6632.2012.06539.x.
- Himmerkus N, Sievers B, Bleich M. (2012) Carbamazepine affects water and electrolyte homoeostasis in rat--similarities and differences to vasopressin antagonism. Nephrol Dial Transplant. 2012 Oct;27(10):3790-8. doi: 10.1093/ndt/gfs107. Epub 2012 May 4.
- Gong Y, Renigunta V, Himmerkus N, Zhang J, Renigunta A, Bleich M, Hou J. (2012) Claudin-14 regulates renal Ca(++) transport in response to CaSR signalling via a novel microRNA pathway. EMBO J. 2012 Feb 28. doi: 10.1038/emboj.2012.49. [Epub ahead of print]
- Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. (2012) Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int. 2012 Jan 11. doi: 10.1038/ki.2011.450. [Epub ahead of print]
2011
- Melzner F, Stange P, Trübenbach K, Thomsen J, Casties I, Panknin U, Gorb SN, Gutowska MA. (2011) Food supply and seawater pCO2 impact calcification and internal shell dissolution in the blue mussel Mytilus edulis. PLoS One. 2011;6(9):e24223. Epub 2011 Sep 16.
- Marques RD, de Bruijn PI, Sorensen MV, Bleich M, Praetorius HA, Leipziger JG. (2011) Basolateral P2X receptors mediate inhibition of NaCl transport in mouse medullary thick ascending limb (mTAL). Am J Physiol Renal Physiol. 2011 Nov 23. [Epub ahead of print]
- Paliege A, Roeschel T, Neymeyer H, Seidel S, Kahl T, Daigeler AL, Mutig K, Mrowka R, Ferreri NR, Wilson BS, Himmerkus N, Bleich M, Bachmann S. (2011) Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb. Am J Physiol Renal Physiol. 2012 Jan 4. [Epub ahead of print]
- Pörtner H-O, MA Gutowska, A Ishimatsu, M Lucassen, F Melzenr, B Seibel (2011) Effects of ocean acidification on nektonic organisms. Ocean Acidification. Eds JP Gattuso, L Hansson. Oxford University Press
- Suffrian K, Schulz KG, Gutowska MA, Riebesell U, Bleich M. (2011) Cellular pH measurements in Emiliania huxleyi reveal pronounced membrane proton permeability. New Phytol. 2011 May;190(3):595-608. doi: 10.1111/j.1469-8137.2010.03633.x. Epub 2011 Feb 7.
- Hu MY, Tseng YC, Stumpp M, Gutowska MA, Kiko R, Lucassen M, Melzner F. (2011) Elevated seawater PCO2 differentially affects branchial acid-base transporters over the course of development in the cephalopod Sepia officinalis. Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1100-14. Epub 2011 Feb 9. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R559.
- Melzner F, Stange P, Trübenbach K, Thomsen J, Casties I, Panknin U, Gorb SN, Gutowska MA. (2011) Food supply and seawater pCO2 impact calcification and internal shell dissolution in the blue mussel Mytilus edulis. PLoS One. 2011;6(9):e24223. Epub 2011 Sep 16
2010
- Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F (2010) Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. J Biol Chem. 2010 Oct 21. [Epub ahead of print]
- Linkermann A, Himmerkus N, Rölver L, Keyser KA, Steen P, Bräsen JH, Bleich M, Kunzendorf U, Krautwald S (2010) Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure. Kidney Int. 2010 Sep 1. [Epub ahead of print]
- Himmerkus N, Vassen V, Sievers B, Goerke B, Shan Q, Harder J, Schröder JM, Bleich M (2010) Human beta-defensin-2 increases cholinergic response in colon epithelium. Pflugers Arch. 2010 Jun;460(1):177-86. Epub 2010 Mar 6.
- Mutig K, Saritas T, Uchida S, Kahl T, Borowski T, Paliege A, Böhlick A, Bleich M, Shan Q, Bachmann S (2010) Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation. Am J Physiol Renal Physiol. 2010 Mar;298(3):F502-9. Epub 2009 Dec 9
- Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D. (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol. 2010 Feb 10. [Epub ahead of print]
- Stoessel A, Himmerkus N, Bleich M, Bachmann S, Theilig F. (2010) Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake. Am J Physiol Renal Physiol. 2010 Jan;298(1):F216-23. Epub 2009 Oct 14
- Hu MY, Sucré E, Charmantier-Daures M, Charmantier G, Lucassen M, Himmerkus N, Melzner F (2010) Localization of ion-regulatory epithelia in embryos and hatchlings of two cephalopods. Cell Tissue Res. 2010 Mar;339(3):571-83. Epub 2010 Feb 2
- Pörtner H-O, Bickmeyer U, Bleich M et al (2010) Measurements of CO2 - sensitive processes. In: Riebesell U, Fabry VJ, Hansson L, Gattuso J-P (ed) Guide to best practices for ocean acidification research and data reporting. Publications Office of the European Union, Luxembourg, pp 137-166
- Trzeciak V (2010) Abenteuer Doktorarbeit. Physiologisch 10, 2-3. Ref Type: Magazine Article
- Gutowska MA, Melzner F, Langenbuch M et al. (2010) Acid-base regulatory ability of the cephalopod (Sepia officinalis) in response to environmental hypercapnia. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY Volume: 180 Issue: 3 Pages: 323-335
2009
- Melzner F, Gutowska MA, Langenbuch M, Dupont S, Lucassen M, Thorndyke MC, Bleich M, Portner HO (2009) Physiological basis for high CO2 tolerance in marine ectothermic animals: pre-adaptation through lifestyle and ontogeny? Biogeosciences 6:2313-31
- Melzner F, Gutowska MA, Hu M, Stumpp M (2009) Acid-base regulatory capacity and associated proton extrusion mechanisms in marine invertebrates: An overview. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY Volume: 153A Issue: 2 Pages: S80-S80
- Gutowska MA, Melzner F (2009) Abiotic conditions in cephalopod (Sepia officinalis) eggs: embryonic development at low pH and high pCO(2). MARINE BIOLOGY Volume: 156 Issue: 3 Pages: 515-519
- Gutowska MA, Melzner F, Langenbuch M, Bock C, Claireaux G, Pörtner HO (2009) Acid-base regulatory ability of the cephalopod (Sepia officinalis) in response to environmental hypercapnia. J Comp Physiol B. 2010 Mar;180(3):323-35. Epub 2009 Oct 17
- Melzner F, Göbel S, Langenbuch M, Gutowska MA, Pörtner HO, Lucassen M (2009) Swimming performance in Atlantic Cod (Gadus morhua) following long-term (4-12 months) acclimation to elevated seawater P(CO2). Aquat Toxicol. 2009 Apr 2;92(1):30-7. Epub 2009 Jan 4
- Shan Q, Himmerkus N, Hou J, Goodenough DA, Bleich M (2009) Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse. Annals of the New York Academy of Sciences 1165:148-51
- Bleich M (2009) Membrane physiology--bridging the gap between medical disciplines. N.Engl.J Med. 360:2012-14
2008
- Gutowska MA, Portner HO, Melzner F (2008) Growth and calcification in the cephalopod Sepia officinalis under elevated seawater pCO(2). MARINE ECOLOGY-PROGRESS SERIES Volume: 373 Pages: 303-309
- Schroder J, Lullmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schroder B, Bleich M, Saftig P (2008) Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol.Cell Biol.
- Himmerkus N, Shan Q, Bleich M (2008) Welche Kräfte treiben den Mg2+-Transport in der Niere? Physiologisch 7:4
- Himmerkus N, Shan Q, Goerke B, Hou J, Goodenough DA, Bleich M (2008) Salt- and acid/base metabolism in claudin-16 knockdown mice - impact for the pathophysiology of FHHNC patients. Am.J Physiol Renal Physiol 295:F1641-F1647
- Reuter S, Velic A, Edemir B, Schröter R, Pavenstädt H, Gabriëls G, Bleich M, Schlatter E (2008) Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection. Pflugers Arch. 2008 Mar 12;Epub ahead of print
- Moussavian MR, Slotta JE, Kollmar O, Menger MD, Gronow G, Schilling MK (2008) Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators. Langenbecks Arch Surg. 2008 May;393(3):303-10. Epub 2008 Feb 19
2007
- Moussavian MR, Slotta JE, Kollmar O, Menger MD, Schilling MK, Gronow G (2007) Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules. Transpl Int. 2007 Oct;20(10):884-94.
- Bleich M, Shan QX (2007) Epithelial K(+) channels: driving force generation and K(+) recycling for epithelial transport with physiological and clinical implications. Sheng Li Xue Bao. 2007 Aug 25;59(4):443-53
- Ronzaud C, Loffing J, Bleich M, Gretz N, Grone HJ, Schutz G, Berger S (2007) Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J.Am.Soc.Nephrol. 18:1679-87
- Kosiek O, Busque SM, Foller M, Shcheynikov N, Kirchhoff P, Bleich M, Muallem S, Geibel JP (2007) SLC26A7 can function as a chloride-loading mechanism in parietal cells. Pflügers Arch.;Ref Type: In Press
- Hou J, Shan Q, Wang T, Gomes AS, Yan Q, Paul DL, Bleich M, Goodenough DA (2007) Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J.Biol.Chem. 282:17114-22
2006
- Schmid H, Boucherot A, Yasuda Y, Henger A, Brunner B, Eichinger F, Nitsche A, Kiss E, Bleich M, Gröne H-J, Nelson P, Schlöndorff D, Cohen CD, Kretzler M (2006) Modular activation of Nuclear Factor- B transcriptional programs in human diabetic nephropathy. Diabetes 55:2993-3003
2005
- Wihler C, Schaefer S, Schmid K, Deemer EK, Münch G, Bleich M, Busch AE, Dingermann T, Somoza V, Baynes JW, Huber J (2005) Renal accumulation and clearance of advanced glycation end products in type 2 diabetic nephropathy: Effect of angiotensin-converting enzyme and vasopeptidase inhibition. Diabetologia;Ref Type: In Press
- Lohn M, Steioff K, Bleich M, Busch AE, Ivashchenko Y (2005) Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation. Eur.J.Pharmacol. 507:179-86
- Gronow G, Kähler W, Koch A, Klause N (2005) Benzoate hydroxylation: a measure of oxidative stress in divers. Adv Exp Med Biol. 2005;566:223-9.
- Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kaab S, Pfeufer A, Uberfuhr P, Dugas M, Steinbeck G, Nabauer M (2005) Functional profiling of human atrial and ventricular gene expression. Pflügers Arch.;Ref Type: In Press
- Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kaab S, Hinterseer M, Kartmann H, Kreuzer E, Dugas M, Steinbeck G, Nabauer M (2005) Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature. Circ.Res. 96:1022-29
- Gronow, G., H. Blumberg, R. Knörle, T.J. Feuerstein, M. Bleich (2005) Postanoxic cytoprotection by GBP-L in rat renal cells. Pflügers Arch 449, S100
2004
- Weyermann A, Vollert H, Busch AE, Bleich M, Gogelein H (2004) Inhibitors of ATP-sensitive potassium channels in guinea pig isolated ischemic hearts. Naunyn Schmiedebergs Arch Pharmacol 369:374-81
- Schafer S, Steioff K, Linz W, Bleich M, Busch AE, Lohn M (2004) Chronic vasopeptidase inhibition normalizes diabetic endothelial dysfunction. Eur.J.Pharmacol. 484:361-62
- Schafer S, Schmidts HL, Bleich M, Busch AE, Linz W (2004) Nephroprotection in Zucker diabetic fatty rats by vasopeptidase inhibition is partly bradykinin B2 receptor dependent. Br.J.Pharmacol. 143:27-32
- Schafer S, Linz W, Vollert H, Biemer-Daub G, Rutten H, Bleich M, Busch AE (2004) The vasopeptidase inhibitor AVE7688 ameliorates Type 2 diabetic nephropathy. Diabetologia 47:98-103
- Pinheiro SV, Simoes e Silva AC, Sampaio WO, de Paula RD, Mendes EP, Bontempo ED, Pesquero JB, Walther T, Alenina N, Bader M, Bleich M, Santos RA (2004) Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension 44:490-496
- Knobloch K, Brendel J, Rosenstein B, Bleich M, Busch AE, Wirth KJ (2004) Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs. Med.Sci.Monit. 10:BR221-BR228
- Kaab S, Barth AS, Margerie D, Dugas M, Gebauer M, Zwermann L, Merk S, Pfeufer A, Steinmeyer K, Bleich M, Kreuzer E, Steinbeck G, Nabauer M (2004) Global gene expression in human myocardium-oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure. J.Mol.Med. 82:308-16
- Goldschimdt I, Grahammer F, Warth R, Schulz-Baldes A, Garty H, Greger R, Bleich M (2004) Kidney and colon electrolyte transport in CHIF knockout mice. Cell Physiol Biochem. 14:113-20
- Gogelein H, Brendel J, Steinmeyer K, Strubing C, Picard N, Rampe D, Kopp K, Busch AE, Bleich M (2004) Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. Naunyn Schmiedebergs Arch Pharmacol 370:183-92
2003
- Gronow, G., W. Kähler, J. Hinrichsen (2004) Oxidative stress by cold preservation in rat renal cells. Pflügers Arch 447, S131
- Wirth KJ, Paehler T, Rosenstein B, Knobloch K, Maier T, Frenzel J, Brendel J, Busch AE, Bleich M (2003) Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs. Cardiovasc.Res. 60:298-306
- Schafer S, Linz W, Bube A, Gerl M, Huber J, Kurzel GU, Bleich M, Schmidts HL, Busch AE, Rutten H (2003) Vasopeptidase inhibition prevents nephropathy in Zucker diabetic fatty rats. Cardiovasc.Res. 60:447-54
2002
- Warth R, Garcia Alzamora M, Kim JK, Zdebik A, Nitschke R, Bleich M, Gerlach U, Barhanin J, Kim SJ (2002) The role of KCNQ1/KCNE1 K+ channels in intestine and pancreas: lessons from the KCNE1 knockout mouse. Pflügers Arch 443:822-28
- Kerst G, Brousos H, Schreiber R, Nitschke R, Hug MJ, Greger R, Bleich M (2002) The oxidant thimerosal modulates gating behavior of KCNQ1 by interaction with the channel outer shell. J.Membr.Biol. 186:89-100
- Gronow, G., W. Kähler, M. Mályusz, A. Koch (2002) Estimating oxidative stress by rebreathing hyperbaric oxygen in divers. Pflügers Arch. 443, S 246
2001
- von Hahn T, Thiele I, Zingaro L, Hamm K, Garcia-Alzamora M, Kottgen M, Bleich M, Warth R (2001) Characterisation of the rat SK4/IK1 K+ channel. Cell Physiol Biochem. 11:219-30
- Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Völkl H, Warth R (2001) Role of KCNE1-dependent K+ fluxes in mouse proximal tubule. J Am Soc Nephrol 12:2003-11
- Schulz-Baldes A, Berger S, Grahammer F, Warth R, Goldschmidt I, Peters J, Schütz G, Greger R, Bleich M (2001) Induction of the epithelial Na+ channel via glucocorticoids in mineralocorticoid receptor knockout mice. Pflügers Arch 443:297-305
- Kunzelmann K, Hubner M, Schreiber R, Levy-Holzman R, Garty H, Bleich M, Warth R, Slavik M, von Hahn T, Greger R (2001) Cloning and function of the rat colonic epithelial K+ channel KVLQT1. J.Membr.Biol. 179:155-64
- Kunzelmann K, Bleich M, Warth R, Levy-Holzman R, Garty H, Schreiber R (2001) Expression and function of colonic epithelial KvLQT1 K+ channels. Clin.Exp.Pharmacol.Physiol 28:79-83
- Kim SJ, Kim JK, Pavenstädt H, Greger R, Hug M, Bleich M (2001) Regulation of slowly activating potassium current (IKs) by secretin in rat pancreatic acinar cells. Journal of Physiology 535:349-58
- Kerst G, Beschorner U, Unsöld B, von Hahn T, Schreiber R, Greger R, Gerlach U, Lang HJ, Kunzelmann K, Bleich M (2001) Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias. Pflügers Arch 443:146-54
- Grahammer F, Warth R, Barhanin J, Bleich M, Hug MJ (2001) The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea. J.Biol.Chem. 276:42268-75
- Grahammer F, Herling AW, Lang HJ, Schmitt-Graff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R (2001) The Cardiac K+ Channel KCNQ1 Is Essential for Gastric Acid Secretion. Gastroenterology 120:1363-71
- Gerlach U, Brendel J, Lang HJ, Paulus EF, Weidmann K, Bruggemann A, Busch AE, Suessbrich H, Bleich M, Greger R (2001) Synthesis and activity of novel and selective IKs channel blockers. J.Med.Chem. 44:3831-37
- Arrighi I, Bloch-Faure M, Grahammer F, Bleich M, Warth R, Mengual R, Barhanin J, Meneton P (2001) Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome. Proc Natl Acad Sci U S A 98:8792-97
- Mályusz. M., W. Kähler, G. Gronow (2001) Hippurate metabolism as a hydroxyl Radical Trapping mechanism in the rat kidney. Kidney Blood Press Res 24, 149-159
2000
- Unsöld B, Kerst G, Brousos H, Hübner M, Schreiber R, Nitschke R, Greger R, Bleich M (2000) KCNE1 reverses the response of the human K+ channel KCNQ1 to cytosolic pH changes, alters its pharmacology and sensitivity to temperature. Pflügers Arch 441:368-78
- Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403:196-99
- Rizzo M, Capasso G, Bleich M, Pica A, Grimaldi D, Bindels RJ, Greger R (2000) Effect of chronic metabolic acidosis on calbindin expression along the rat distal tubule. J.Am.Soc.Nephrol.2000.Feb.,11.(2.):203.-10. 11:203-10
- Mauricio C, Slawik M, Heitzmann D, von Hahn T, Warth R, Bleich M, Greger R (2000) Deoxycholic acid (DOC) affects the transport properties of distal colon. Pflügers Arch 439:532-40
- Kim SJ, Kerst G, Schreiber R, Pavenstädt H, Greger R, Hug MJ, Bleich M (2000) Inwardly rectifying K+ channels in the basolateral membrane of rat pancreatic acini. Pflügers Arch 441:331-40
- Heitzmann D, Warth R, Bleich M, Henger A, Nitschke R, Greger R (2000) Regulation of the Na+2Cl-K+ cotransporter in isolated rat colon crypts. Pflügers Arch 439:378-84
- Hasselblatt P, Warth R, Schulz-Baldes A, Greger R, Bleich M (2000) pH regulation in isolated in vitro perfused rat colonic crypts. Pflügers Arch 441:118-24
1999
- Warth R, Hamm K, Bleich M, Kunzelmann K, von Hahn T, Schreiber R, Ullrich E, Mengel M, Trautmann N, Kindle P, Schwab A, Greger R (1999) Molecular and functional characterisation of the small Ca2+-regulated K+ channel (rSK4) of colonic crypts. Pflügers Arch 438:437-44
- Waldegger S, Fakler B, Bleich M, Barth P, Hopf A, Schulte U, Busch AE, Aller SG, Forrest JN, Jr., Greger R, Lang F (1999) Molecular and functional characterization of s-KCNQ1 potassium channel from rectal gland of Squalus acanthias. Pflügers Arch 437:298-304
- Mall M, Bleich M, Kuehr J, Brandis M, Greger R, Kunzelmann K (1999) CFTR-mediated inhibition of epithelial sodium conductance in human colon is defective in cystic fibrosis. Am.J.Physiol. 277:G709-G716
- Greger R, Bleich M, Warth R, Thiele I, Forrest JN (1999) The cellular mechanisms of Cl- secretion induced by C-Type natriuretic peptide (CNP). Experiments in isolated in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 438:15-22
- Greger R, Heitzmann D, Hug MJ, Hoffmann EK, Bleich M (1999) The Na+2Cl-K+ cotransporter in the rectal gland of Squalus acanthias is activated by cell shrinkage. Pflügers Arch 438:165-76
- Bleich M, Hug MJ, Heitzmann D, Warth R, Greger R (1999) Evidence for Na+/Ca2+ exchange in the rectal gland of Squalus acanthias. Pflügers Arch 439:49-51
- Bleich M, Warth R, Schmidt-Hieber M, Schulz-Baldes A, Hasselblatt P, Fisch D, Berger S, Kunzelmann K, Kriz W, Schütz G, Greger R (1999) Rescue of the mineralocorticoid receptor knock-out mouse. Pflügers Arch 438:245-54
- Gronow, G., M. Moussavian, M. Mályusz (1999) Effect of hydroxyl radical scavengers in renal cortical cells. Adv. Exp. Biol. Med. 487, 345-352
- Gronow, G., W. Kähler, M. Moussavian, M. Mályusz (1999) Quantification of oxidant stress by hydroxybenzoate in reoxygenated renal cortical cells. Pflügers Arch, 437, R 181
1998
- Weyand B, Warth R, Bleich M, Greger R (1998) Hypertonic cell shrinkage reduces the K+ conductance in rat colonic crypt cells. Pflügers Arch 436:227-32
- Warth R, Bleich M, Thiele I, Lang F, Greger R (1998) Regulation of the Na+2Cl-K+ cotransporter in in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 436:521-28
- Warth R, Thiele I, Bleich M, Greger R (1998) The role of cytosolic Ca2+ in the secretion of NaCl in isolated in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 436:133-40
- Thiele I, Warth R, Bleich M, Waldegger S, Lang F, Greger R (1998) Osmotically induced conductance and capacitance changes in in vitro perfused rectal gland tubules of Squalus acanthias. Kidney Blood Press Res 21:317-24
- Nielsen MS, Warth R, Bleich M, Weyand B, Greger R (1998) The basolateral Ca2+-dependent K+ channel in rat colonic crypt cells. Pflügers Arch 435:267-72
- Mall M, Bleich M, Schürlein M, Kühr J, Seydewitz HH, Brandis M, Greger R, Kunzelmann K (1998) Cholinergic ion secretion in human colon requires coactivation by cAMP. Am.J.Physiol. 275:G1274-G1281
- Mall M, Bleich M, Greger R, Schreiber R, Kunzelmann K (1998) The amiloride inhibitable Na+ conductance is reduced by CFTR in normal but not in CF airways. J Clin Invest 102:15-21
- Greger R, Thiele I, Warth R, Bleich M (1998) Does stimulation of NaCl-secretion in in vitro perfused rectal gland tubules of Squalus acanthias increase membrane capacitance? Pflügers Arch 436:538-44
- Gloy J, Henger A, Fischer K-G, Nitschke R, Bleich M, Mundel P, Schollmeyer P, Greger R, Pavenstädt H (1998) Angiotensin II modulates cellular functions of podocytes. Kidney International 54:S-168-S-170
- Bleich M, Thiele I, Warth R, Greger R (1998) pH-regulatory mechanisms in in vitro perfused rectal gland tubules of Squalus acanthias. Pflügers Arch 436:248-54
- Berger S, Bleich M, Schmid W, Cole TJ, Peters J, Watanabe H, Kriz W, Warth R, Greger R, Schütz G (1998) Mineralocorticoid receptor knock out mice: Pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A 95:9424-29
- Malyusz, M., Barth, A., Gronow, G. (1998) Hydroxyl radical trapping by benzoate in the kidney, another possible aim of hippurate metabolism. Pflügers Arch. 435, R. 219
- Klause, N., T. Arendt, M. Lins, G, Gronow (1998) Hypoxic renal tissue damage by endothelin-mediated arterial vasoconstriction during radioangiography in man. Adv. Exp. Biol. Med. 454:225-235
- Gronow, G., M. R. Moussavian, M. Mályusz (1998) Posthypoxic cellular integrity in glycine-preserved renal tubules is improvede by OH-radical scavengers. Pflügers Arch, 435:R 218
1997
- Willmann JK, Bleich M, Rizzo M, Schmidt-Hieber M, Ullrich KJ, Greger R (1997) Amiloride inhibitable Na+ conductance in rat proximal tubule. Pflügers Arch 434:173-78
- Gloy J, Henger A, Fischer K-G, Nitschke R, Mundel P, Bleich M, Schollmeyer P, Greger R, Pavenstädt H (1997) Angiotensin II depolarizes podocytes in the intact glomerulus of the rat. J Clin Invest 99:2772-81
- Fraser G, Portnoy M, Bleich M, Ecke D, Yaron N, Greger R, Schwartz B (1997) Characterisation of sodium and chloride conductances in preneoplastic and neoplastic murine colonocytes. Pflügers Arch 434:801-8
- Bleich M, Briel M, Busch AE, Lang HJ, Gerlach U, Gögelein H, Greger R, Kunzelmann K (1997) KvLQT channels are inhibited by the K+ channel blocker 293B. Pflügers Arch 434:499-501
- Bleich M, Ecke D, Schwartz B, Fraser G, Greger R (1997) Effects of the carcinogen dimethylhydrazine (DMH) on the function of rat colonic crypts. Pflügers Arch 433:254-59
- Rudolph, N, G. Gronow, T. Mályusz, M. Stöckle (1997) Comparison of renal and hepatic in-vitro ammoniagenesis from glutamine, glycine and hippurate in different species including man. Pflüger´s Arch. 433:P 613
- Malyusz, M., Rudolph, N., Barth, A., Gronow, G., Malyusz, T. (1997) Hippurate as a source of renal and hepatic ammoniagenesis in different species. In: Nutritional and acid-base aspects of amino acid metabolism. Contrib. Nephrol. Ed. by O´Donovan, D.J., Endou, H.., Schoolwerth, A.C., Tizianello, A., Walls, J. pp. 93 – 100, Karger, Basel
- Malyusz, M., Barth, A., Rudolph, N., Gronow, G., Malyusz, T. (1997) Comparison of renal and hepatic in-vitro ammoniagenesis from glutamine, glycine and hippurate in different species including man. Pflügers Arch. 433, R 166
- Mályusz, M, N. Rudolph, A. Barth, G. Gronow, T. Mályusz (1997) Hippurate as a source of renal and hepatic ammoniagenesis in different species. Contrib. Nephrol. 121:93-100
- Gronow, G., M. Mályusz, M. Stöckle (1997) Glycine effects in renal tubular cells of man. Pflüger´s Arch. 433: P613
- Gronow, G., M. Mályusz, N. Klause, K. Weichert-Jacobsen, M. Stöckle (1997) Glycine preserves human renal tubules during cold preservation. Eur. J. Clin. Invest. 27: A32
- Gronow, G., M. Mályusz, N. Klause (1997) PO2-dependent ultrafiltration of middle-weight protein is modified by protective amino acids. Adv. Exp. Med. Biol. 411: 267-274
- Franke, M., Malyusz, M., Gronow, G., Malyusz, T. (1997) The effect of hippurate on the renal syntheisi of 4-hydroxyproline. Pflügers Arch. 433, R 166
1996
- Warth R, Riedemann N, Bleich M, Van Driessche W, Busch AE, Greger R (1996) The cAMP-regulated and 293B inhibited K+ conductance of rat colonic crypt base cells. Pflügers Arch 432:81-88
- Suessbrich H, Bleich M, Ecke D, Rizzo M, Waldegger S, Lang F, Szabo I, Lang HJ, Kunzelmann K, Greger R, Busch AE (1996) Specific blockade of slowly activating IsK channels by chromanols - impact on the role of IsK channels in epithelia. FEBS Letters 396:271-75
- Ecke D, Bleich M, Greger R (1996) The amiloride inhibitable Na+ conductance of rat colonic cells is suppressed by forskolin. Pflügers Arch 431:984-86
- Ecke D, Bleich M, Schwartz B, Fraser G, Greger R (1996) The ion conductances of colonic crypts from dexamethasone-treated rats. Pflügers Arch 431:419-26
- Ecke D, Bleich M, Greger R (1996) Crypt base cells show forskolin-induced Cl- secretion but no cation inward conductance. Pflügers Arch 431:427-34
- Bleich M, Riedemann N, Warth R, Kerstan D, Leipziger J, Hör M, Van Driessche W, Greger R (1996) Ca2+-regulated K+ and non-selective cation channels in the basolateral membrane of rat colonic crypt base cells. Pflügers Arch 432:1011-22
- Gronow, G., Piotraschke, E., Mályusz, M. (1996) Reduction of proteinuria by glycine in the hypoxic rat kidney. Pflügers Arch. 431: P179
- Gronow, G., O. Jung, M. Mályusz (1996) Modulation of oxygen deprivation-induced cellular dysfunction by glycine and alanine. Funktionsanalyse Biologischer Systeme 25:235-243
1995
- Lohrmann E, Burhoff I, Nitschke RB, Lang HJ, Mania D, Englert HC, Hropot M, Warth R, Rohm W, Bleich M, Greger R (1995) A new class of inhibitors of cAMP-mediated Cl- secretion in rabbit colon, acting by the reduction of cAMP-activated K+ conductance. Pflügers Arch 429:517-30
- Ecke D, Bleich M, Lohrmann E, Hropot M, Englert HC, Lang HJ, Warth R, Rohm W, Schwartz B, Fraser G, Greger R (1995) A chromanol type of K+ channel blocker inhibits forskolin- but not carbachol mediated Cl- secretion in rat and rabbit colon. Cell Physiol Biochem 5:204-10
- Bleich M, Köttgen M, Schlatter E, Greger R (1995) Effect of NH4+/NH3 on cytosolic pH and the K+ channels of freshly isolated cells from the thick ascending limb of Henle's loop. Pflügers Arch 429:345-54
- Siepmann, M., G. Gronow, W. Kirch (1995) Ibopamine in patients with congestive heart failure and different degrees of renal function. Am. J. Therap. 2:469-477
1994 und älter
- Mályusz, M., A. Hackl, P. Wrigge, M. Lange, T. Mályusz, H. Sick, G. Gronow (1994) Ammonia production from hippurate by the rat kidney in vivo. Ren. Phys. Biochem., 17, 307 - 315
- Klause, N., W. Niedermayer, R. Wronski, G. Gronow (1994) Verhinderung des akuten Nierenversagens durch nephroprotektive Aminosäuren. Int. Med. Notf. Med. 31:322-323
- Klause, N., G, Gronow, M. Mályusz, W. Niedermayer (1994) Adverse effect of extracellular acidosis on hypoxic and posthypoxic cellular injury in renal tubules. Pflügers Arch. 426:R133
- Gronow, G., N. Klause (1994) Potentiation of posthypoxic damage by histidine in isolated renal tubules. Funktionsanalyse biologischer Systeme 22:151-158
- Gronow, G., N. Klause M. Mályusz (1994) Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules. Adv. Exp. Med. Biol. 361:585-589
- Gronow, G., M. Mályusz, W. Niedermayer, N. Klause (1994) Diminution of histidine-induced reoxygenation damage by glycine in posthypoxic renal cells. Adv. Exp. Med. Biol. 345:717-722
- Schlatter E, Bleich M, Hirsch J, Markstahler U, Fröbe U, Greger R (1993) Cation specificity and pharmacological properties of Ca2+-dependent K+ channel of rat cortical collecting ducts. Pflügers Arch 422:481-91
- Hollunder-Reese F, Mohrmann M, Bleich M, Greger R (1991) K+, Cl- and Nonselective Channels in Opossum Kidney Cells. Cell Physiol Biochem 1:238-50
- Greger R, Bleich M, Schlatter E (1990) Ion channels in the thick ascending limb of Henle's loop. Renal Physiol Biochem 13:37-50
- Bleich M, Schlatter E, Greger R (1990) The luminal K+ channel of the thick ascending limb of Henle's loop. Pflügers Arch 415:449-60
- Gronow, G., N. Klause, M. Mályusz (1990) Support of hypoxic renal cell volume regulation by glycine. Adv. Exp. Med. Biol. 277:705-712
- Gronow, G. N. Klause (1989) Support of posthypoxic renal respiratory function by specific amino acids. Funktionsanalyse biologischer Systeme 19: 225-231